In further support to the upregulation of key effectors for tumour surveillance, lepadin A (1) increased synthesis of IL-6 and reduced the secretion of the immunosuppressive cytokine IL-10 in the supernatants of the co-cultures with DCs, while did not affect the levels of IL-1β and TNFα (Additional file 2: Fig. S4). This evidence concerns the gene IL10 and neoplasm.