These genes were downstream targets of mTOR signaling in prostate cancer.79 Moreover, the potent and ATP-competitive mTOR inhibitor repressed mRNA translation and suppressed cellular proliferation.80 Another study has revealed that mRNAs that are controlled by mTORC1 are 5’ terminal oligopyrimidine (TOP) motifs. The gene discussed is MTOR; the disease is Familial prostate cancer.