This study suggested that DLEU1 enhanced endometrial carcinogenesis through its binding with mTOR protein and activation of the PI3K/AKT/mTOR axis.112 Chen and colleagues have noticed that overexpression of HAGLROS was associated with worse outcomes in patients with gastric cancer.113 Silencing of HAGLROS suppressed the expression of the mTOR leading to increased expression of ATG9A and ATG9B. This evidence concerns the gene PIK3CA and gastric cancer.