NBR2 regulates cell growth, autophagy, and apoptosis in response to energy-related stresses through mTOR signaling.114 MALAT1 lncRNA was found to act as oncogenic lncRNA in hepatocellular carcinoma (HCC) via splicing factor SRSF1/mTOR/S6K1 axis.115 Overexpression of LINC00152 was reported to increase HCC tumorigenesis regulating the EpCAM expression through mTOR signaling cascade.116 Another study displayed that H19 lncRNA was downregulated in human pituitary adenomas. This evidence concerns the gene MALAT1 and hepatocellular carcinoma.