TUG1 and central nervous system cancer: The upregulation of the GAS5 lncRNA inhibited the tumorigenesis of gastric carcinoma through the miRNA-106a-5p/AKT/mTOR axis in both in vitro and nude mice xenograft models.120 Restoration of the GAS5 expression enhanced the sensitivity of the cisplatin in glioma through mTOR-mediated autophagy.121 Depletion of CASC9 suppressed the tumor growth of OSCC xenograft by autophagy-dependent apoptosis via AKT/mTOR pathway.122 Silencing of TUG1 lncRNA caused apoptosis of HCC cells through mTOR signaling.