Notably, we found that the protein and mRNA expression levels of SIRT1 were aberrantly increased in NSCLC cells harboring KRASMut and in KRASG12D mouse lung tumors compared with normal lung epithelial cells and with tumor-adjacent normal tissues and KrasWT mouse lung tissues, respectively (Fig. 1). The gene discussed is SIRT1; the disease is non-small cell lung carcinoma.