In addition, the MAF gene, an AP-1 complex component with a potential antagonistic effect on the JUN and FOS family proteins, is located next to WWOX. The mRNA expression of MAF and cadherin genes (CDH1, CDH3, and CDH11) was highly downregulated in both ovarian cancer cell lines and tissues (Fig. 5c, d, Supplementary Fig. 3a). Here, WWOX is linked to ovarian cancer.