In addition, the MAF gene, an AP-1 complex component with a potential antagonistic effect on the JUN and FOS family proteins, is located next to WWOX. The mRNA expression of MAF and cadherin genes (CDH1, CDH3, and CDH11) was highly downregulated in both ovarian cancer cell lines and tissues (Fig. 5c, d, Supplementary Fig. 3a). The gene discussed is MAF; the disease is ovarian carcinoma.