KCTD17 expression is increased in the livers of obese mice and patients with NAFLD/nonalcoholic steatohepatitis (NASH), leading to the degradation of pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) to prolong insulin signaling by dephosphorylating AKT97. Here, PHLPP2 is linked to metabolic dysfunction-associated steatohepatitis.