For example, SETX (Senataxin), AQR (Aquarius), WRN (Werner syndrome), BLM (Bloom syndrome), RTEL1 (Regulator of telomere elongation helicase 1), PIF1 (Petite integration factor 1), FANCM (Fanconi anemia complementation group M), ATRX (alpha-thalassemia/mental retardation, X-linked), CasDinG (CRISPR-associated DinG protein), and several DEAD/H-box proteins are reported to resolve R-loops. This evidence concerns the gene SETX and Bloom syndrome.