For example, SETX (Senataxin), AQR (Aquarius), WRN (Werner syndrome), BLM (Bloom syndrome), RTEL1 (Regulator of telomere elongation helicase 1), PIF1 (Petite integration factor 1), FANCM (Fanconi anemia complementation group M), ATRX (alpha-thalassemia/mental retardation, X-linked), CasDinG (CRISPR-associated DinG protein), and several DEAD/H-box proteins are reported to resolve R-loops. The gene discussed is SETX; the disease is alpha thalassemia spectrum.