For example, when compared to cognitively normal subjects, plasma neuronal EV levels of pTau-181 and pTau-396 were not only higher in the AD patients but when these neuronal EVs were injected into wildtype mouse brains, greater pathologic pTau protein levels were observed, suggesting that neuronal EVs can seed and propagate Tau pathology onto normal brains [41]. Here, MAPT is linked to Alzheimer disease.