Thus, the current meta-analysis was performed to summarize the available evidence regarding the effects of dietary ALA supplementation inflammatory markers in serum (CRP, TNF-α, and IL-6), blood pressure ([BP], including systolic BP [SBP] and diastolic BP [DBP]), and lipid profile (TG, TC, LDL cholesterol, and HDL cholesterol in serum) in individuals with obesity or overweight as compared with the placebo. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.