Thus, the current meta-analysis was performed to summarize the available evidence regarding the effects of dietary ALA supplementation inflammatory markers in serum (CRP, TNF-α, and IL-6), blood pressure ([BP], including systolic BP [SBP] and diastolic BP [DBP]), and lipid profile (TG, TC, LDL cholesterol, and HDL cholesterol in serum) in individuals with obesity or overweight as compared with the placebo. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.