A second study by Martinod and colleagues probes role of PADI4 and PADI2 in NETs and the regulation of von Willebrand factor and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13) in the innate immune response to bacterial infection, using bacteremia patient samples (Martens et al. [19]). Here, PADI2 is linked to bacterial infectious disease with sepsis.