TDP-43 was also found to accumulate in limbic areas of the majority of Alzheimer’s Disease (AD) patients [2–4], in addition to amyloid-β (Aβ) and tau proteins, and has been recently defined as limbic-predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC) [5]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.