Indeed, we and others have observed that symptomatic AD cases with LATE-NC, i.e., AD(LATE-NC+), display higher Braak neurofibrillary tangle (NFT) stages and an increased p-tau burden [6, 10, 11], probably due to common upstream factors that influence both pathologies, such as the APOE ε4 allele [9, 12–14]. Here, APOE is linked to Alzheimer disease.