MAPT and Alzheimer disease: Notably, when quantifying the local p-tau severity, we found that animals injected with AD(LATE-NC+) extracts showed a higher number of p-tau-positive particles in both hemispheres compared to control lysate injected animals (ipsilateral: R2 = 0.39, p = 0.0007; contralateral: R2 = 0.26, p = 0.0120) and to AD (LATE-NC-)-injected animals (ipsilateral, p = 0.0163; contralateral, p = 0.0373) (Fig. 3d-e, Suppl.