In our cohort, the mean Braak LBD stage among both AD groups was similar, with AD(LATE-NC+) cases showing a slightly higher mean (1.4) compared to AD(LATE-NC-) cases (0.25), so it is likely that α-synuclein plays only a minor role in exacerbating p-tau pathology in AD. This evidence concerns the gene MAPT and Alzheimer disease.