APOE and Alzheimer disease: We found that AD(LATE-NC+) cases exhibited significantly increased p-tau pathology in both regions when compared to controls (CA1, p = 0.0003; frontal cortex p < 0.0001) and to AD (LATE-NC-) cases (CA1, p = 0.0066; frontal cortex, p = 0.0097, Fig. 1 a-b, e), even after correcting for age and APOE ε4 status.