TARDBP and Alzheimer disease: The levels of total (physiological) TDP-43 were decreased in FTLD-TDP cases compared to AD(LATE-NC-) and AD(LATE-NC+) in both regions, reaching significance in the entorhinal region (p = 0.0028 and p = 0.0018, respectively; multiple linear regressions) (Fig. 1h-i).