After confirming the Ripk2flox/flox;Tmem119CreERT2/wt (μKO) mice displayed sufficient deletion of Ripk2 in isolated microglia following tamoxifen injection (Fig. 8B), we subjected μKO and appropriate control mice (WT) to 45 min-tMCAO and found a significant reduction in total hemisphere infarct size 48 h after stroke in our μKO mice compared to WT (Fig. 8C, D). This evidence concerns the gene RIPK2 and stroke disorder.