To assess the effect of Ripk2 deletion on infarct size after stroke, we first induced 45 min-transient middle cerebral artery occlusion (tMCAO) in mice sufficient (Ripk2+/+) and deficient (Ripk2−/−) for the Ripk2 gene and sacrificed the mice 24 h later. Here, RIPK2 is linked to stroke disorder.