PADI4 and adenoviridae infectious disease: Second, considering adenovirus vectors are inflammatory and immunogenic and can be cytotoxic at high multiplicities of infection in the nervous system [58], however, we did not test the inflammatory response of adenovirus infection in the informative controls, which would cause false positive effects on our results and confound the effects of PAD4 overexpression in the context of the acute inflammatory response of TBI.