In RAF-driven colorectal cancer, statins can inhibit the isoprenylation of Ras protein which is mediated by the downstream intermediates FPP and GGPP of the cholesterol synthesis pathway, and inhibit the activation of the PI3K/AKT pathway as well as Hippo pathway to inhibit the activity of cell growth [122]. The gene discussed is AKT1; the disease is colorectal cancer.