In gastric cancer, PADI4 with genetic susceptibility may up-regulate CXCR2, KRT14 and TNF-α by disrupting the p53 signaling pathway to regulate the microenvironment, angiogenesis, proliferation, differentiation and migration, apoptosis and inflammation of cells, thus promoting the occurrence of gastric cancer [149]. The gene discussed is TP53; the disease is gastric cancer.