The cinnamyl piperidine derivative compound 4 g could selectively inhibit the neddylation of gastric cancer cells mediated by cullin1 and cullin3, and promote the apoptosis of gastric cancer cells induced by mitochondria and Nrf2-Keap1 signaling pathway, thus inhibiting the growth and metastasis of tumor cells [98]. Here, KEAP1 is linked to gastric cancer.