SNEP3 activates the transcriptional activity of forkhead box protein C2 (FOXC2) and increases the expression of N-cadherin through the deSUMOylation of FOXC2, which activates the transformation of epithelial mesenchyme as well as enhances the invasion and metastasis of gastric cancer cells [17]. The gene discussed is FOXC2; the disease is gastric cancer.