TP53 and colorectal cancer: Although the specific mechanism of UBA2 and SUMOylation remains unclear, inhibition of de-SUMOylation activation of UBA2 can reduce the levels of cyclingB1, Bcl-2, DMD2, p-AKT and affect p53/DMD2/p21 signaling pathway, thus influencing the transitions of the colorectal cancer cell cycle from G1/S and G2/M [53].