In drug-resistant cells of colorectal cancer, the aberrantly expressed SENP1 could increase the SUMOyaltion of HIF-α, which leads to the conversion of intracellular signal transduction pathway from Wnt/β-catenin to EGFR/IKKα/β/NF-kB, thus reducing the sensitivity of cancer cells to irinotecan [32]. This evidence concerns the gene NFKB1 and colorectal cancer.