It is noteworthy that, under ROS induction, the oligomeric peroxiredoxin PRDX1 could specifically enhance the interaction between CUL5 and NEDD8-coupled enzyme UBE2F, thereby enhancing the neddylation of NOXA and promoting protein degradation, which is beneficial for colorectal cancer growth and can partially explain the drug resistance of etoposide during the treatment of colorectal cancer as well [79]. Here, CUL5 is linked to colorectal cancer.