In addition, SUMOyaltion of deacetylase 2 (HDAC2) can protect colon cancer cells from chemotherapeutic-induced genotoxic stress by activating kinase RSK1 and enhancing the regulatory transcription of nuclear factor-KB (NF-KB), so high levels of HDAC2 correlated with chemotherapeutic-drug resistance in colon cancer [30]. Here, RPS6KA1 is linked to malignant colon neoplasm.