In contrast to ERα, E2 induces an increase in ERβ levels in colon cancer cells and promotes ERβ palmitoylation through the activation of the P38/MAPK pathway, and palmitoylated ERβ in turn regulates the E2-induced apoptotic process and plays an anti-proliferation role [180, 181]. This evidence concerns the gene ESR2 and malignant colon neoplasm.