In malignant peripheral nerve sheath tumors (MPNST) EYA4 is over-expressed [9], whilst it is down-regulated in esophageal adenocarcinoma [10, 11], hepatocellular carcinoma [12], lung cancer [13] and colorectal cancer [14], where the EYA4 gene promoter has been found to be hypermethylated. This evidence concerns the gene EYA4 and esophageal adenocarcinoma.