However, the serine/threonine phosphatase activity of EYA4 is the one that shows more significant outcomes, as observed not only by decreased tumor burden to lungs (Fig. S2C-E), but also by a lesser number of metastatic foci to the liver, with an average of 2 foci for S/T phosphatase deficient mutant, compared to 6 for EYA4 shRNA2 and 7 for Y phosphatase deficient mutant (Fig. 2J). This evidence concerns the gene EYA4 and neoplasm.