KLK3 and posterior cortical atrophy: Specific recommendations are based on patients’ initial risk stratification, which factors in life expectancy, prostate specific antigen (PSA) levels, digital rectal exam results as well as pathology characteristics from systematic prostate biopsy (i.e., Gleason Score and extent of gland involvement). PCa is relatively unique among other malignancies due to favorable outcomes in men regardless of their choice for initial management.