Male and higher CRP levels have been suggested to be the significant risk factors of ILD in patients with pSS [21–24], however, Guo T et al. found that serum CRP levels have no significant difference between pSS with ILD and pSS without ILD [25], our present study did not observe the association of ILD with male and CRP in patients with pSS. Here, CRP is linked to interstitial lung disease.