Serum bilirubin levels were significantly and negatively correlated with ESR in patients with pSS (r=-0.321,p = 0.002), while serum bilirubin had no significantly correlation with CRP in patients with pSS, and serum bilirubin levels were not significantly correlated with age, complement C3, complement C4, immune globulin A, immune globulin G, immune globulin M, alanine aminotransferase and aspartate aminotransferase in patients with pSS. This evidence concerns the gene GPT and peeling skin syndrome.