The majority of the studies found significant enrichment of CD4 in the tumor and the TME in surgical resection specimens after CRT (p = 0.006, p = 0.009, p = 0.004, respectively) (Table 4);23,29 however, one study contradicted these results and showed that poor responders had significant enrichment of CD4 density compared with poor responders (p ≤ 0.001).30 The gene discussed is CD4; the disease is neoplasm.