In the present study, a renal tubule epithelial cell-specific Sirt2 conditional knockout mouse line (Sirt2tKO) was utilized, showing that the induction of SIRT2 deletion in kidney renal tubule epithelial cells 7 days after UUO, a time point when renal fibrosis was well established (Fig. 2a), significantly promoted the progression and expansion of renal fibrosis compared to control mice. This evidence concerns the gene SIRT2 and renal fibrosis.