Immunohistochemistry (Fig. 1k, l) and immunoblotting (Fig. 1m) also showed substantial downregulation of SIRT2 protein in fibrotic mouse kidney tissues induced by UUO and uIRI (Fig. S2a–d), both of which are characterized by substantial renal fibrosis [24, 25]. Here, SIRT2 is linked to renal fibrosis.