In the current study, we found that SIRT2 expression were reduced in the liver of CCL4-induced hepatic fibrosis (Fig. S10a), and specific deletion of Sirt2 in hepatocyte aggravated CCl4-induced hepatic fibrosis and upregulated TGF-β regulated genes expression (Fig. S10b–d). The gene discussed is CCL4; the disease is Hepatic fibrosis.