At day 7 post-UUO surgery, the extent of renal fibrosis was induced in Sirt2tKO kidneys (Fig. 2a–c); they displayed higher levels of CTGF, FN1, COL3A1, and α-SMA compared to WT mice after UUO surgery (Fig. 2d–h). Here, COL3A1 is linked to renal fibrosis.