Notably, EIF4A3 expression was significantly related to both immune and molecular subtypes in several cancer types such as ACC, BRCA, COAD, HNSC, KIRP, LIHC, LUSC, OV, PRAD, STAD and UCEC, indicating that EIF4A3 may be a crucial factor in these cancers and further research is required to confirm its potential as a precise treatment target. Here, EIF4A3 is linked to cancer.