When analysing the frequencies of helper (CD4+ CD8−), cytotoxic (CD8+ CD4−) and unconventional CD4+ CD8+, CD4− CD8− and gamma-delta (γδ: Vδ1 and Vδ2) T cells subsets, we saw reduced Vδ1 T cells in the MIS-C patients when compared to controls. This evidence concerns the gene CD8A and COVID-19–associated multisystem inflammatory syndrome in children.