To further investigate BEX2-inhibited apoptosis in NSCLC cells, two independent siRNAs targeting BEX2 sensitized H1299 cells to doxorubicin-induced apoptosis, as shown by an increase in CASP3 and PARP-1 cleavage (Supplementary Fig. 6A). Here, BEX2 is linked to non-small cell lung carcinoma.