To determine the potential implication of PYCR1 pY135 in tumor growth in vivo, HCT116 or SW620 cells with or without PYCR1 depletion, or with respective expression of WT rPYCR1, rPYCR1 Y135F or rPYCR1 T238A were subcutaneously injected into athymic nude mice. Here, PYCR1 is linked to neoplasm.