PAX4 and metabolic process: To further explore the role of rare coding variants in the PAX4 gene on T2D risk, we accessed aggregated gene-level exome-sequencing association data from 52 K individuals deposited in the Common Metabolic Disease Portal (https://t2d.hugeamp.org) and in 281,852 individuals from UKBioBank (https://www.ukbiobank.ac.uk/).