PD-1/PD-L1 blockage is clinically beneficial mostly by disturbing T cell immune function.9 Early study has explored the treatment of ipilimumab in hematologic malignancies in the setting of allogeneic stem cell transplantation disease progression.15 In addition, inhibition of PD-1/PD-L1 combined with other targeted therapy has also been proven to improve outcomes in AML patients.14 Whereas, there is still a lack of systematic demonstration to apply anti-PD-1/PD-L1 therapy to AML. The gene discussed is CD274; the disease is acute myeloid leukemia.