NUMB and ocular melanoma: In ocular melanoma, histone lactylation induces m6A reader protein YTHDF2 expression, which recognizes the PER1 and TP53 mRNAs and enhances their degradation, promoting tumorigenesis.44 In prostate and lung adenocarcinomas, Numb/Parkin pathway deficiency exerts an increase in lactate production and histone lactylation followed by transcriptional alteration of neuroendocrine-associated genes.45 However, whether STAT5 participates in the modification of histone lactylation has not been reported.