These factors can activate signaling pathways like Ras–Raf–MEK (mitogen-activated protein kinase kinase)–extracellular signal–regulated kinase (ERK), MEKK1/c-Jun N-terminal kinase (JNK), PI3K/Akt/mTOR, Wnt/b-catenin, Janus kinase–signal transducer and activator of transcription-3 (STAT3), insulin-like growth factor (IGF) receptor, hepatocyte growth factor receptor (HGFR), and epidermal growth factor receptor (EGFR) that can result in the initiation, invasion, and metastasis of HCC (3, 4, 5). Here, STAT3 is linked to hepatocellular carcinoma.