Many physiological and pathological processes have been shown to be regulated by m6A writer proteins (METTL3/METTL14/WTAP), including circadian rhythms (20), DNA damage response (21), stem cell differentiation (22, 23), brown adipose tissue development (8, 9), NASH (6, 7), and diabetes (10, 24), in both m6A-dependent and -independent manners. This evidence concerns the gene METTL3 and diabetes mellitus.