Many disease processes such as NASH, obesity, and diabetes have been found to be regulated by m6A RNA writer proteins such as methyltransferase like 3 (METTL3) and Wilm’s tumor 1–associating protein (WTAP) by altering m6A RNA modification or chromatin accessibility (6, 7, 8, 9, 10, 11). The gene discussed is WTAP; the disease is obesity due to melanocortin 4 receptor deficiency.