To further characterize the underlying mechanism for T-cell infiltration, we tested several cytokine receptors that are well known related to CD8 T-cell infiltration including C–X–C chemokine receptors 3 and 4 and C–C chemokine receptor type 4 (CCR4); only surface expression of C–X–C chemokine receptor 3 significantly increased in tumor-infiltrating CD8+ T cells in BATF2 KD tumor (Fig. 4, I and J). The gene discussed is BATF2; the disease is neoplasm.