Taken together, the results in Supplemental Table S1, Fig. 1A, supplemental Fig. S5, and (7) suggest that elevated NEFA in LDL but not in plasma of patients with obesity reflect, at least in part, increased enzymatic activity of Lp-PLA2, perhaps compounded by a small decrease in albumin’s ability to sequester NEFA. Here, PLA2G7 is linked to obesity due to melanocortin 4 receptor deficiency.