VCP and amyotrophic lateral sclerosis: Lastly, to determine whether there is crosstalk between mutSOD1 and VCP in an intact nervous system in vivo, we used an established C. elegans ALS model for mutSOD1 toxicity.47–49 Worms expressing mutSOD1 in the nervous system display a significant locomotor deficit as measured by reduced speed in liquid compared to WT animals (Figures 7C and S7E).