Intriguingly, within this group we detected several ALS-associated proteins including KIF5A, FUS, VCP, DCTN1, MATR3, SFPQ, TUBA4A, PRPH, and STMN2 (Figure S2E), suggesting that long-lived proteins (or proteins with slower degradation kinetics) may be contributing to the vulnerability of MNs to ALS disease mechanisms. Here, MATR3 is linked to amyotrophic lateral sclerosis.