Levels of serum IL-6 (Fig. 8A), TNF-α (Fig. 8B), and IL-10 (Fig. 8C) in sepsis mice treated with anti-PD-L1 antibody significantly declined at 24 (P = 0.004), 48 (P = 0.006), and 72 h (P = 0.005), respectively; there were no significant changes at other time points, showing no statistical significance. This evidence concerns the gene TNF and Sepsis.