To investigate whether the anti-PD-L1 antibody affected monocyte function, we selected three important cytokines, IL-6, IL-10, and TNF-α, used ELISA to assess cytokine production in the CLP-induced sepsis model and anti-PD-L1 antibody-treated septic mice at 24, 48, and 72 h. The gene discussed is IL10; the disease is Sepsis.