This study discovered that rs4759314 (A > G) was associated with an elevated BC risk in the heterozygote AG genotype, dominant, co-dominant, and overdominant models; however, there is no significant difference in rs920778 (C > T) genotype and allele frequencies, as well as no connection between HOTAIR (rs4759314, rs920078) variants and disease stages or histological grades. The gene discussed is HOTAIR; the disease is breast cancer.