Dietary supplements, such as curcumin (CURC) and ursolic acid (UA), are utilized in several anti-inflammatory conditions, largely targeting NF-κB, AKT, and STAT3, common cancer molecular pathways.6 Investigators have suggested a variety of dietary and natural products with therapeutic benefits for prostate cancer, yet few have undergone prospective testing in humans. This evidence concerns the gene NFKB1 and prostate cancer.