While the androgen receptor is highly studied and known in prostate cancer progression and current treatment, Akt plays a role in the PI3K/AKT pathway of tumorigenesis including apoptosis and proliferation of PCa cells as a part of the NF-κB axis.264 Therefore, with the Akt pathway shown to be studied in CURC and UA through our review in combination with NF-κB, these pathways should be further investigated to understand the exact axis points of the effects from CURC and UA. Here, NFKB1 is linked to Familial prostate cancer.