ZIKV infection leads to an increase in ROS production by the body to combat the infection, with a concomitant inhibition of the activation of antioxidant transcription factor Nrf2 and the accompanying down-regulation of antioxidant protein gene expression and their biosynthesis (HO-1 SOD and CAT) [44], as well as a reduction in GSH levels [165]. This evidence concerns the gene NFE2L2 and Zika virus infectious disease.