On the other hand, the reduced efficiency of transcription factor Nrf2 in ZIKV infection, which usually corresponds to an increased efficiency of pro-inflammatory transcription factor NF-κB, is evident in the increased generation of pro-inflammatory cytokines, such as TNF-α and IL-6, IL-1β, which recruit other cell types to the infected tissue and, by activating them, exacerbate inflammation. This evidence concerns the gene TNF and Zika virus infectious disease.