To summarize, our analysis identified six risk proteins (NAMPT, TIE1, CBR1, PDE4D, PAFAH1B2, NCF2) and seven protective proteins (FSTL1, PTPN4, SOCS3, GZMB, GPC1, C1QC, FCGR3B) that are causally associated with MM risk. The gene discussed is TIE1; the disease is Miyoshi myopathy.