The present study describes the screening of 189 CAF marker genes by single cell sequencing, and the construction of a six-gene (CAV1, IGFBP3, PLAC9, PLAU, SELM, and SOD3) prognostic signature to evaluate the influence of CAF marker genes on the prognosis of patients with PAAD. Here, PLAC9 is linked to pancreatic adenocarcinoma.