TP53 and neoplasm: Other pathways enriched in low-risk group included the PPAR signaling pathway, primary immunodeficiency, and the gut immune network for IGA production, and so on (Fig. 5G), whereas other pathways enriched in high-risk group included tumor proliferation-related pathways, such as the cell cycle, homologous recombination and the p53 signaling pathway (Fig. 5H).