Indeed, a signature emerged and demonstrated that among the 8 proteins overexpressed in the p53 signature, some of them are linked with a poor prognosis as follows: i) CAVIN1, SPTAN1 and FBLN5 for OC; ii) (EIF3B) for renal, head and neck cancers iii) MOB1B, EMILIN-2, EIF3B for liver cancer. This evidence concerns the gene FBLN5 and head and neck cancer.