Furthermore, we used immunohistochemistry and western blot-based protein determinations to ascertain whether proteoglycans phosphacan, neurocan, brevican, versican and BRAL1, as well as Tenascin R and associated NR axonal membrane protein neurofascin, are altered in the overall WM neuropil and around individual NRs in the PFC WM in MDD and in rats subjected to CUS. Here, NCAN is linked to major depressive disorder.