Both the SCN5A-ΔKPQ/ + and SCN5A-ΔQKP/ + mouse models report many characteristic phenotypes such as prolonged QT interval, a more pronounced T wave, prolonged APD, arrhythmias, and sudden death, which make them suitable for examining LQT3 mechanisms and pathogenesis273,274. This evidence concerns the gene SCN5A and long QT syndrome 3.