MEC1 or proliferating primary CLL cells treated with RAP or AZD8055 alone or in combination with IB, showed elevated peEF2T56 with mTOR-selective inhibitors, indicating an inactivation of the eEF2K/eEF2 axis and a reduction in translation elongation, which did not occur with IB alone (Fig. 7B&C & Supplementary Fig. 14). Here, EEF2K is linked to B-cell chronic lymphocytic leukemia.