Mirroring the phosphorylation events seen in splenocytes of PKCα-KR-transduced Mx1-Raptor cKO transplanted mice (Fig. 5H), there was a significant decrease in peEF2KS366 in samples treated with RAP or AZD8055, which was enhanced in the RAP/IB combination, together with an increase in peEF2T56 in CLL patient samples when treated with RAP or AZD8055, which reached significance with AZD8055 treatment (Fig. 6I & Supplementary Fig. 12D, E). Here, RPTOR is linked to B-cell chronic lymphocytic leukemia.