In mice transplanted with Mx1-Raptor-PKCα-KR cells and then treated with polyI:C after establishment of CLL-like disease, an increase in peEF2T56 was observed in the absence of Raptor, and a significant decrease in Cyclin A expression, a protein associated with transition through the S-G2/M phase of the cell cycle (Supplementary Fig. 13A). Here, CCNA2 is linked to B-cell chronic lymphocytic leukemia.