We highlight for the first time, the importance of the eEF2K/EF2 axis in regulating protein translation elongation downstream of mTORC1-regulated pathways in CLL models which, through an elevation eEF2 expression and reduced negative regulation of eEF2, enables the generation of proteins involved in cell survival and proliferation. This evidence concerns the gene EEF2 and B-cell chronic lymphocytic leukemia.