In multivariate analysis, severe sarcopenia (OR 4.59; 95% CI 1.21, 17.46, P = 0.025) and IGF-1 levels (OR 0.98; 95% CI 0.96, 0.99, P = 0.023) were independently associated with fragility fracture (Table 4). Here, IGF1 is linked to sarcopenia.