IGHE and allergic disease: Severe allergic reactions are rare but may cause death.55,56 Pharmacovigilance data from Korea shows that alpha-gal-specific IgE detection can accurately predict cetuximab-induced hypersensitivity before administration.53 As per the US Prescribing Information, the incidence of severe infusion reactions to cetuximab is 2.2%.57 It may be advisable to test patients for alpha-gal IgE antibodies using FDA-cleared methods before initiating cetuximab, particularly in regions, like the southeastern US, where these reactions are common.