IL10 and Cowden disease: 28,34 In the interleukin-10 (IL-10) knockout model of chronic colitis, BM-MSCs were also found to decrease the reactive species O2−, H2O2, and suppress subsequent lipid peroxidation.33 Although the relationship between endogenous MSC cellular sources and IBD is unclear, MSCs isolated from the AT of CD patients exhibit high levels of lactoferrin, which has ROS scavenging properties.50 The conditioned medium had an enhanced therapeutic capacity in experimental colitis compared to MSCs from uninflamed controls with low-lactoferrin levels.