Craniosynostosis has been described in individuals with pathogenic variants in other genes of the RAS/MAPK pathway including BRAF (Davis et al., 2019; Ueda et al., 2017), KRAS (Addissie et al., 2015; Brasil et al., 2012; Kratz et al., 2009; Lo et al., 2009; Schubbert et al., 2006; Ueda et al., 2017), PPP1CB (Bertola et al., 2017), SHOC2 (Takenouchi et al., 2014), PTPN11 (Davis et al., 2019; McDonald et al., 2018; Ueda et al., 2017), RAF1 (Rodriguez et al., 2019), and HRAS (Nagai et al., 2021; Weaver et al., 2022). The gene discussed is HRAS; the disease is craniosynostosis.