Among this group of disorders, craniosynostosis appears to be consistently associated with Noonan, CFC, and Costello syndromes with pathogenic variants most frequently reported in BRAF, HRAS, KRAS, and PTPN11 (Table 2) (Ueda et al., 2017; Weaver et al., 2022; Zollino et al., 2017). The gene discussed is BRAF; the disease is Costello syndrome.