Among this group of disorders, craniosynostosis appears to be consistently associated with Noonan, CFC, and Costello syndromes with pathogenic variants most frequently reported in BRAF, HRAS, KRAS, and PTPN11 (Table 2) (Ueda et al., 2017; Weaver et al., 2022; Zollino et al., 2017). This evidence concerns the gene PTPN11 and craniosynostosis.