Most of the predicted target genes of 6 miRNAs (miR-193a-3p, miR-370-3p, miR-365-3p, miR-2137, miR-3473b and miR-3473e) were also differentially expressed hub genes related to ART-induced anti-schistosomiasis liver fibrosis, including Tlr4, Cyth4, Irf8, Nckap1l, Myo1F, Src, Fscn1, Adamtsl2, Prkcd, Surf4 and Ddit4 (S5 Table). The gene discussed is IRF8; the disease is schistosomiasis.