GDF-15 does not affect susceptibility to COVID-19 in the population, IVW (OR = 1.01, 95% CI 0.99–1.03; P = .35); weighted median (OR = 1.01, 95% CI 0.99–1.04; P = .34); MR-Egger (OR = 0.99, 95% CI 0.92–1.08; P = .95). This evidence concerns the gene GDF15 and COVID-19.