The effect of GDF-15 on hospitalization due to COVID-19 was not observed, IVW (OR = 1.02, 95% CI 0.97–1.08; P = .48); Weighted median (OR = 0.99, 95% CI 0.94–1.06; P = .91); MR-Egger (OR = 1.09, 95% CI 0.87–1.37; P = .52). The gene discussed is GDF15; the disease is COVID-19.