As a Mendelian randomization study, the instrumental variable was strongly correlated with exposure and not correlated with outcome (5 × 10−8),by this criterion, it does not violate the conditions of Mendelian randomization, and it is estimated that GDF-15 may not mediate the impact of COVID-19 outcomes through Coronary Artery Disease. Here, GDF15 is linked to coronary artery disorder.