RIPK1 and Parkinson disease: Accumulating evidence suggests that activated (phosphorylated) RIPK1, RIPK3, and MLKL form protein aggregates and amyloidogenic fibers that promote necroptosis and neurodegeneration.[44] Another pathological hallmark of PD is the appearance of intracellular inclusions containing α-synuclein, termed Lewy bodies,[5] and these inclusions appear to trigger apoptosis and necroptosis.