TNFRSF21 and Alzheimer disease: Other members of the TNF receptor superfamily (TNFRSF), such as DR3, TRAILR1 (DR4), TRAILR1 (DR5), DR6, and p75 NTR, also recruit TRADD upon ligand activation, which then propagates to downstream cell death signaling pathways.[45–48] Research on TRADD functions in INDs have focused primarily on AD,[48,49] and to our best knowledge, the current study is the first to demonstrate the involvement of TRADD in PD-related necroptosis, although this requires further confirmation in PD mouse models.