In brief, the evidence for necroptosis in PD can be summarized as follows: differential expression of RIPK1, TRADD, and 32 other necroptosis-related genes in brain samples from PD patients; enrichment of necroptosis-related GO terms and KEGG pathways among DEGs between patients and controls; and efficient construction of a PPI network from NRDEGs. This evidence concerns the gene RIPK1 and Parkinson disease.