At present, the imbalance of this pathway has been found in many autoimmune diseases.[17] Recently, it has been found that JAK inhibitors can alleviate the activation of salivary gland epithelial cells, thereby relieving inflammation and lymphocyte infiltration, and improving dryness symptoms.[18] The regulation of cytokine responses is also a function of PTPRC. This evidence concerns the gene PTPRC and autoimmune disease.