CD45RChigh and CD45RClow T cells produced interleukin-2 (IL-2), IL-4, IL-10, and IL-13.[19] Phenekos et al reported that the proinflammatory cytokines IL-2, IL-4, and IL-10 were distinctly raised in HT.[20] This suggests that proinflammatory cytokines may be a significant pathway for CD45 to influence the pathogenesis of HT. The gene discussed is IL10; the disease is hematocrit.