INS and polycystic ovary syndrome: They modulate the activity of peroxisome proliferator-activated receptors (PPARs), thereby influencing lipid metabolism and insulin sensitivity.[35] Additionally, ω-3 PUFAs have anti-inflammatory properties that reduce systemic inflammation, a key contributor to endocrine dysregulation in PCOS.[36,37] These combined actions contribute to improved metabolic and hormonal profiles in PCOS patients.