HIF1A and ischemic stroke: These results support the hypothesis that reduced expression of genes in the HIF-1alpha neuroprotective pathway in aging may contribute to poor prognosis in the elderly following traumatic brain injury.[87] Impaired HIF-1 transcription activity is associated with defective cerebral recovery from ischemic stroke in aged rats.[88] Impaired HIF-α may contribute to age-associated cognitive decline during hypoxic events.[85]