AMPH and Pruritus: These interneurons may be the cellular basis for inhibiting pruritus by painful stimuli.[17] Meanwhile, anti-amphiphysin antibodies are able to deactivate gabaergic interneurons by reducing the expression of the Na+/K+/2Cl2- cotransporter.[18] Thus, it is speculated that it may be one of the mechanisms through which anti-amphiphysin antibodies cause paraneoplastic pruritus.