In the present study, four typical inflammation molecules (TNF‐α, IL‐1β, IL‐18, and VCAM‐1) were analyzed, which showed all four molecules were increased in LPS‐induced HK‐2 cells, however, their concentration could be declined by KDM2B knockdown, indicating that KDM2B promotes inflammation in sepsis model. This evidence concerns the gene TNF and Sepsis.